Members

Kok Hao CHEN, PhD

Kok Hao CHEN, Ph.D.

Principal Scientist II

Shijie, Nigel CHOU, Ph.D

Shijie, Nigel CHOU, Ph.D.

Senior Scientist I

Wan Yi SEOW

Wan Yi SEOW

Senior Research Officer I

Xinrui ZHOU, Ph.D

Xinrui ZHOU, Ph.D.

Senior Scientist I

Yen Ling LEE

Yen Ling LEE

Lead Research Officer II

Dao Tuc Tu, Ph.D

Dao Tuc Tu, Ph.D.

Scientist

Jiao, CAO, Ph.D

Jiao, CAO, Ph.D.

Scientist

Gallery

Jose Guijarro Nuez

A*STAR ARAP-MRC DTP Scholar (PhD student)

Former Members

● Maurice Lee, 2020-2025.

● Vipul Singhal, 2018-2024. Head of Computational Biology at Integrated Biosciences

● Nigel Chou Shijie, 2017-2023. GIS Fellow at Genome Institute of Singapore

● Lurong Wang, 2022-2024. Research Officer at Genome Institute of Singapore

● Jiamin Toh, 2019-2024. Research Officer at Genome Institute of Singapore

● Norbert Ha, 2019-2024. Biomedical Scientist at Delta Electronics

● Jack Petts-Lewis, 2021-2023. Graduate Student at University of Warwick

● Lingfan Jiang, 2019-2023. Research Scientist at KLA

● Jazlynn Tan, 2022. University of Toronto

● Jeeranan Boonruangkan, 2018-2022. Biofourmis

● Jie Lin Jolene Goh, 2016-2022. Veranome Biosystems

● Mike Jin-An Huang, 2018-2021. 1910 Genetics

● Paul Cheng, 2018-2021. Veranome Biosystems

● Kaviya Selva Raju, 2018-2020. Research Associate at Applied Materials

● Siyi Chen, 2018. Senior Scientist at Maiden Therapeutics

● Christabelle Goh, 2018. Scientist II at Applied Materials

● Ziqing, Winston Zhao, 2018-2019. Assistant Professor at National University of Singapore

● Teck Por Lim, 2018-2019.

● Mei Lun Chow, 2018. Project Officer at Nanyang Technological University

Publications

FISHnCHIPs
BANKSY
Split-FISH
MERFISH

Publication list

Zhou, X.*, Seow, W. Y.*, Ha, N., Cheng, T. H., Jiang, L. F., Boonruangkan, J., Goh, J. J. L., Prabhakar, S., Chou, N.#, Chen, K. H.#, Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes, Nature Communications, (2024) DOI: 10.1038/s41467-024-46669-y.

Singhal, V.*, Chou, N.*, Lee, J., Yue, Y., Liu, J., Chock, W. K., Lin, Li, Chang, Y., Teo, E., Lee, H. K., Chen, K. H.#, Prabhakar, S.#, BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis, Nature Genetics, (2024) DOI: 10.1038/s41588-024-01664-3.

Goh, J. J. L.*, Chou, N.*, Seow, W. Y., Ha, N., Cheng, C. P. P., Chang, Y., Zhao, Z. W., Chen, K. H. Highly specific multiplexed RNA imaging in tissues with split-FISH. Nature Methods, (2020) https://doi.org/10.1038/s41592-020-0858-0.

Li, H., Courtois, E. T., Sengupta, D., Tan, Y., Chen, K. H., Goh, J. J. L., et al. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nature Genetics (49), 708–718 (2017).

Moffitt, J. R.*, Hao, J.*, Wang, G.*, Chen, K. H., Babcock, H. P. & Zhuang, X. High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization. P.N.A.S. 113 (39), 11046-11051 (2016).

Chen, K. H.*, Boettiger, A. N.*, Moffitt, J. R.*, Wang, S. & Zhuang, X. Spatially resolved, highly multiplexed RNA profiling in single cells. Science 348, aaa6090 (2015).

Cha, T. G., Baker, B.A., Salgado J., Bates C.J., Chen K.H., Chang A.C., Han J.C., Strano M.S., & Choi J.H. Understanding oligonucleotide-templated nanocrystals: Growth mechanisms and surface properties. ACS Nano 6, 8136–8143 (2012).

Bates, M., Dempsey, G. T., Chen, K. H. & Zhuang, X. Multicolor super-resolution fluorescence imaging via multi-parameter fluorophore detection. ChemPhysChem 13, 99–107 (2012).

Chen, K. H., Hobley, J., Foo, Y. L. & Su, X. Wide-field single metal nanoparticle spectroscopy for high throughput localized surface plasmon resonance sensing. Lab Chip 11, 1895–1901 (2011).

Dempsey, G. T.*, Vaughan, J. C.*, Chen, K. H.*, Bates, M. & Zhuang, X. Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging. Nature Methods 8, 1027–1036 (2011).

Ishitsuka, Y., Okumus, B., Arslan, S., Chen,q K. H. & Ha, T. Temperature-independent porous nanocontainers for single-molecule fluorescence studies. Anal. Chem. 82, 9694–9701 (2010).

Mateo-Alonso, A., Ehli, C., Chen, K. H., Guldi, D. M. & Prato, M. Dispersion of single-walled carbon nanotubes with an extended diazapentacene derivative. J. Phys. Chem. A 111, 12669–12673 (2007).

Choi, J. H., Chen, K. H. & Strano, M. S. Aptamer-capped nanocrystal quantum dots: A new method for label-free protein detection. J. Am. Chem. Soc. 128, 15584–15585 (2006).

Fun

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Contact Us

We’re located on level 5 of the Genome Institute of Singapore, at the Biopolis research campus in the One-North area.

Our mailing address is: Genome Institute of Singapore (GIS), 60 Biopolis Street Level 5, Genome Building, Singapore 138672

Positions available. Email:chenkh(at) gis.a-star.edu.sg